The Wellness Zone Podcast

Science-based conversations about Anti-Inflammation nutrition, Metabolic Engineering™, Chronic Disease prevention, and overall Health and Wellness. Hosted by Mary Perry and Dr. Barry Sears, NYT best-selling author, ”Enter The Zone”.

Episodes

Feb 25, 2025

7 min

GLP-1 drugs are now being used to treat addiction. But while GLP-1 drugs can be powerful, they come with serious side effects. The good news? You can achieve similar benefits naturally through Metabolic Engineering®, which is also based on calorie restriction—but designed for long-term health.

Feb 18, 2025

6 min

From the water you drink to the food you eat, these tiny plastic particles are nearly impossible to avoid. Tune in to learn what you can do to minimize your exposure and protect your health—plus how all this relates back to your metabolism.

Obesity and Aging

Jan 28, 2025

Jan 28, 2025

10 min

Have you ever wondered why centenarians—those remarkable individuals who live to 100 or beyond—are almost never obese? It’s not just a coincidence. Obesity is far more than a number on the scale; it’s a chronic inflammatory condition that speeds up aging and steals away your healthspan—the precious years you spend vibrant, active, and free from disease

Jan 17, 2025

11 min

There’s no approved drug to treat Alzheimer’s. But your diet can play a crucial role in prevention. Reducing insulin resistance may be one of the most powerful ways to protect your brain. That’s where Metabolic Engineering® comes in. In this episode, join Mary Perry and me to learn how this groundbreaking dietary approach can help lower your risk of cognitive decline and keep your brain healthier for years to come.

Jan 8, 2025

8 min

Ultra-processed foods often get a bad rap—and for good reason.
But what if we could re-engineer foods we love—like pasta, bread, and pastries—to not only keep their nutrients intact but also activate natural pathways that reduce hunger and inflammation caused by obesity?
Well, we can. It’s called Zone Foods, and it’s not science fiction—it’s science.

Nov 5, 2024

8 min

GLP-1 drugs are often hailed as ‘miracle treatments’. But what makes them effective isn’t magic; it’s the activation of AMPK. This same metabolic pathway can be naturally activated through diet. Dr. Barry Sears and Maruy Perry dive into how this works and why AMPK might be the key to unlocking better health with less of a need for medication.

Oct 23, 2024

10 min

How old are you, really? While your chronological age is just a number, your biological age reveals the true state of your body’s health. In this episode of the Wellness Zone, Dr. Barry Sears and Mary Perry explore the intriguing science of epigenetics—what switches our genes on or off—and how it impacts aging.

Oct 15, 2024

11 min

In this episode of The Wellness Zone podcast, Dr. Barry Sears and Mary Perry break down how your metabolism plays a key role in not just living longer, but living better. Tune in to discover the science behind improving your quality of life, and how small changes today can set you up for a healthier future.

Oct 2, 2024

10 min

In this episode of the Wellness Zone Podcast, Dr. Barry Sears and Mary Perry, Director of Clinical Trials, explain the three stages of Metabolic Engineering, using a rocket analogy to break it down. Stage one is a calorie-restricted diet, like the Zone diet, to activate AMPK. Stage two involves omega-3s to reduce inflammation, and stage three introduces polyphenols to ensure a smooth transition to the Zone. Together, these stages set you on the path to a longer, healthier life.

Sep 11, 2024

7 min

From ancient willow bark to modern aspirin, all the way to today’s GLP-1, we'll explore how these mighty remedies have evolved. And guess what? They all share a secret superpower: activating AMPK!

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